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Pavithra, S.
- A First Report on the Antiproliferative activity of Sodium Copper Chlorophyllin from Endangered Medicinal Plant Rhinacanthus nasutus on HepG2 and HeLa Cell Lines
Abstract Views :169 |
PDF Views:3
Authors
S. Pavithra
1,
N. Banu
2
Affiliations
1 Department of Biotechnology, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Vels University, Velan Nagar, P.V. Vaithiyalingam Road, Pallavaram, Chennai – 117, Tamil Nadu, IN
2 Department of Biotechnology, Vels Institute of Science, Technology and Advanced Studies (VISTAS), VELS University, Velan Nagar, P.V. Vaithiyalingam Road, Pallavaram, Chennai - 117, Tamil Nadu, IN
1 Department of Biotechnology, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Vels University, Velan Nagar, P.V. Vaithiyalingam Road, Pallavaram, Chennai – 117, Tamil Nadu, IN
2 Department of Biotechnology, Vels Institute of Science, Technology and Advanced Studies (VISTAS), VELS University, Velan Nagar, P.V. Vaithiyalingam Road, Pallavaram, Chennai - 117, Tamil Nadu, IN
Source
Research Journal of Pharmacy and Technology, Vol 10, No 1 (2017), Pagination: 325-329Abstract
Plants are the richest source of bioactive compounds and they have been used as medicine also. Chlorophyllin, a water soluble derivative of chlorophyll (chl) in which magnesium has been replaced with copper and the phytol chains lost. Chlorophyllin has been used by human population for over 50 years for medicinal purposes with no adverse effects. Chlorophyllin is a promising chemopreventive agent to block cancer primarily by inhibiting carcinogen such as AFB1. The objective was to extract the bioactive pigment chloropyllin from Rhinacanthus nasutus and characterize by IR and NMR and evaluate the effect of chlorophyllin on inhibition of cell proliferation in HepG2 and HeLa cell lines. The HepG2 and HeLa cell lines was exposed with different concentrations of chlorophyllin, and found that there was a significant dose dependent reduction in cell viability. The IC50 value at 48Hrs was 62.5μg/ml for Rhinacanthus nasutus Chlorophyllin on HepG2 Cell line and HeLa cell line. This is the first report of chlorophyllin from fresh leaves of Rhinacanthus nasutus on HepG2 and HeLa cell lines. It also suggests the benefit of these natural compounds against HepG2 and HeLa cell lines.Keywords
Sodium Copper Chlorophyllin, Rhinacanthus nasutus, HepG2 Cell Lines, HeLa Cell Lines.- Free Radical Scavenging Activity and Total Antioxidant Capacity of Tin Chlorophyllin from Morinda citrifolia L
Abstract Views :161 |
PDF Views:1
Authors
S. Pavithra
1,
N. Banu
2
Affiliations
1 Department of Biotechnology, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Vels University, Chennai, Tamil Nadu, IN
2 Department of Biotechnology, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Vels University, Chennai, Tamil Nadu, IN
1 Department of Biotechnology, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Vels University, Chennai, Tamil Nadu, IN
2 Department of Biotechnology, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Vels University, Chennai, Tamil Nadu, IN
Source
Research Journal of Pharmacy and Technology, Vol 10, No 2 (2017), Pagination: 453-455Abstract
Medicinal plants are the rich source of harmless medicines, and used for the treatment of various diseases for thousands of years. They can provide biologically active molecules and lead structures for development of modified derivatives with enhanced activity or reduced activity. Green plants synthesize and preserve a variety of biochemical products, many of which are extractable and used as chemical feed stocks or as raw material for several scientific investigations. Tin chlorophyllin, a water soluble sodium salt of Chlorophyll is one among the family of phytochemical compounds. The central metal atom, magnesium of chlorophyll has been replaced with tin and the phytol chains lost in chlorophyllin. The antioxidant activity of tin chlorophyllin from the leaves of Morinda citrifolia L. was investigated by using in vitro antioxidant models such as DPPH scavenging assay and Phosphomolybdenum method. The free radical scavenging activity of tin chlorophyllin on the stable radical 1, 1- diphenyl-2-picrylhydrazyl (DPPH) was evaluated and the percentage of inhibition was determined. By phosphomolybdenum method, the total antioxidant capacity of tin chlorophyllin was determined and the absorbance values were expressed as the number of gram equivalent of ascorbic acid. The results demonstrate the potential antioxidant activity of tin chlorophyllin and support its possible role in human health protection and disease prevention.Keywords
Tin Chlorophyllin, Morinda citrifolia L., DPPH, Free Radicals, Phosphomolydenum.- A Review on the Bioactivity of Various Metallochlorophyllin-A Chlorophyll Derivative
Abstract Views :149 |
PDF Views:1
Authors
N. Banu
1,
S. Pavithra
2
Affiliations
1 Department of Biotechnology, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Vels University, IN
2 Department of Biotechnology, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Vels University, IN
1 Department of Biotechnology, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Vels University, IN
2 Department of Biotechnology, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Vels University, IN
Source
Research Journal of Pharmacy and Technology, Vol 10, No 2 (2017), Pagination: 480-486Abstract
Medicinal plants are the rich source of harmless medicines, and used for the treatment of various diseases for thousands of years. They can provide biologically active molecules and lead structures for development of modified derivatives with enhanced activity or reduced activity. The isolation and identification of active principles and elucidation of the mechanism of action of a drug is of paramount importance. Hence, works in both mixture of traditional medicine and single active compounds are very important. One such compound is metallochlorophyllin, a water soluble analogue of the ubiquitous green pigment chlorophyll. Metallochlorophyllin can neutralize several physically relevant oxidants and may decrease oxidative damage induced by chemical carcinogens and radiation. It also acts as an effective inhibitor of aflatoxin hepatocarcinogenesis in animal models by blocking carcinogen bioavailability. Further anti-cancer effects of metallochlorophyllin including antioxidant activity, inhibition of enzymatic activity that converts inert procarcinogens into active carcinogens; stimulation of enzymatic activity that promotes the elimination of toxic substances from the body; protection from radiation; and antitumor activity have likewise been evidenced by controlled studies. The metallochlorophyllins are compounds worthy of further study, with the potential to provide great benefit to human health.Keywords
Chlorophyll, Metallochlorophyllin, Anti-Oxidant, Anti-Microbial, Anti-Carcinogenic.- Screening of Antimicrobial Activity of tin Chlorophyllin from Morinda citrifolia L
Abstract Views :161 |
PDF Views:3
Authors
S. Pavithra
1,
N. Banu
2
Affiliations
1 Department of Biotechnology, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Vels University, Chennai, Tamil Nadu, IN
2 Department of Biotechnology, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Vels University, Chennai, Tamil Nadu, IN
1 Department of Biotechnology, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Vels University, Chennai, Tamil Nadu, IN
2 Department of Biotechnology, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Vels University, Chennai, Tamil Nadu, IN